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Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol

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Key findings: Placebo Group : Minimal weight loss 1mg Daily Group : Average 2.8kg weight loss 5mg Daily Group : Comparable results to 1mg 10mg Daily Group : No additional benefits over 1mg This research established that doses above 1mg (1000 mcg) provide no additional benefits, supporting our 300-500 mcg dosing recommendations

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