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These changes can happen on the lips, tongue, cheeks, or gums

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Further research into this process could help to understand how these cells protect against cancer, and could potentially lead to new avenues of research into anti-cancer therapeutics. Joint senior author, Dr Peter Campbell (Wellcome Sanger Institute), said: People who have smoked heavily for 30, 40 or more years often say to me that its too late to stop smoking the damage is already done

You come to the end of your pipe and caramel is detectable