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Geneva: WHO Press

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The working group also used GRADE to determine the certainty of the evidence and strength of the recommendation (Box 1).21 Appendices 47 (available at www.cmaj.ca/lookup/doi/10.1503/cmaj.241584/tab-related-content) provide the evidence-to-decision frameworks the task force used to develop recommendations

Caffeine, however, has been shown to reduce the development of such tolerance, presumably by impairing the detox ability of the liver and inhibiting DNA repair.157 Now, lest you think this is a good thing, consider the big picture