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10.1172/JCI118709 74

In the meantime, the e-cigarette market exploded and, driven by flavored products, youth usage of e-cigarettes began to increase, from 1.5% of high school students in 2011 to 16% in 2015

The hundred trillion microbes and viruses residing in every human body, which outnumber human cells and contribute at least 100 times more genes than those encoded on the human genome (Ley et al., 2006), offer an immense accessory pool for inter-individual genetic variation that has been underestimated and largely unexplored (Savage, 1977

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