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100 Identifying triggers: Recognizing situations, emotions (stress, boredom, sadness), or environments that increase food noise

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NF-kB (nuclear factor-kB) is a transcription factor that regulates many immune and inflammatory response genes.[ref] It can turn up the heat at times when inflammatory cytokines, such as IL-6, IL-13, and TNF-alpha , are needed.[ref] NF-kB also regulates melatonin production in the pineal gland and in cells that produce melatonin

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Countering this with more robust study designs, such as randomised clinical trials, is fraught with ethical and logistical issues that are unlikely to be overcome (Evans-Brown et al, 2009)