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27 Toxic megacolon (TM), which can occur in either CD or UC, is defined as an acute dilatation of the transverse colon (greater than 6 cm in diameter) and a loss of haustration on radiologic examination in a case of severe colitis

Arcus Senilis (White Ring in the Eye) A gray or white arc around the cornea, often called arcus senilis as someone ages, their blood vessels widen, allowing more cholesterol and other fats to build up in the eyes

This metabolic reprogramming and these alterations are closely intertwined with genetic and epigenetic changes, which activate oncogenes and inactivate tumor suppressor genes, resulting in stepwise cellular transformation and oncogenesis [99, 443, 444] (Fig

reference dose (mg/kg.d) 15,16