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Assessing the lung cancer risk reduction potential of cMRTPs before or soon after they are introduced into the market is hampered by (i) the absence of clinical risk markers that are predictive of future lung cancer development, (ii) the latency of lung cancer manifestation (decades of smoking), and (iii) the slow reduction in excess risk upon smoking cessation and a fortiori upon switching to a cMRTP

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4,5 Successful smoking cessation after discharge appears to be more common in hospitalized patients prescribed NRT who also receive behavioral counseling

To test this hypothesis for MLE-12 cells, they were treated with 0% or 8% CSE for 8 generations, then transfected with SIRT1 siRNA