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The WHO reports that approximately 8% of couples worldwide and 10% to 15% of those in industrialized nations experience infertility [5], and that male factor infertility is involved in 30% to 35% of all cases [6]

Advanced fibrosis at diagnosis has been independently associated with a smoking history of more than 10 pack, with an odds ratio (OR) of 1.63 (95% CI 1.192.24) [62]