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Three maintenance strategies have clinical support: Strategy 1: Continue full-dose therapy

Research has shown that centelloside selectively regulates the Nrf2 pathway, increasing the expression of Nrf2, GPX4, and SLC7A11 in a kidney injury model, inhibiting oxidative stress and ferroptosis, alleviating LPS-induced vacuolation and glomerular mesangial expansion in kidney tissues, to reduce AKI (188)

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This includes assessment for nutritional deficiencies, progression of diabetic neuropathy, introduction of other medications, or development of comorbid conditions known to cause secondary RLS

Patients with progressive kidney failure and usually with less than 10 to 15 percent function usually need dialysis to clear toxins from the body