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A study of 3D organotypic nasal epithelial culture showed that the impact of IQOS was substantially lower than CS in terms of cytotoxicity, tissue morphology, proinflammatory mediators, ciliary function, transcriptome perturbations, and miRNA expression profiles 59

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Their relationship was marred however by affairs on both sides, as well as a language barrier, and eventually ended in an amicable divorce in 1972

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