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The same study confirmed dose-dependent increases in GH without significant changes in other pituitary hormones (prolactin, TSH, LH, FSH, cortisol), supporting its selectivity for the GH axis

A 2021 study on vegan adults found high-dose oral methylcobalamin (1,000 mcg/day) effectively raised serum holotranscobalamin (the active B12 marker) to optimal levels within months, outperforming lower doses in maintaining steady stores

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Studies using chondrocyte cell models have investigated whether the GH C-terminal fragment influences cartilage matrix synthesis, chondrocyte proliferation, and growth factor expression in bone and cartilage biology research contexts