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Long-term use of NSAIDs, corticosteroids, or DMARDs may lead to side effects like gastric irritation, liver strain, or lowered immunity

You take medications known to interfere with B12 absorption, including metformin, proton pump inhibitors, or H2 receptor antagonists

The combination of multiple medications affecting gastrointestinal motility should be carefully evaluated, and patients should be monitored for both efficacy and tolerability

When NNMT activity is inhibited, these methyl donors become available for other methylation reactions in the body

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