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The expression of GCH1 induces lipid remodeling in cells, inhibiting ferroptosis by selectively preventing the consumption of PLs with two PUFA tails [25]

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Sonigo, C

This results in an overall rate of free radical oxidation propagation that is over 8-fold faster for conjugated linolenic acid 43 , providing a chemical basis for the distinct ferroptosis-inducing activity of this lipid class above a threshold concentration

A Meta-Analysis of Oxidative Stress Markers in Depression