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At the adipose tissue level, the combined GIP and GLP-1 agonism reduces M1 macrophage infiltration and pro-inflammatory cytokines such as leptin, increases adiponectin, and enhances insulin sensitivity, thereby improving adipocyte dysfunction.39 GIP additionally increases the storage capacity of adipose tissue, which lowers the likelihood of ectopic fat deposition and reduces the extent of visceral fat.1,5,39 Furthermore, it has demonstrated neuroprotective effects and promotes bone formation1 (Table 2)
Take12 capsules daily, preferably divided between morning and evening
L-Theanine, which often pairs with caffeine in supplements, can control dopamine levels while affecting serotonin and GABA [18]
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Additionally, LIGHT levels were found to have a negative correlation with DEXA parameters
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