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In human ORAI1 knock-in mice, DS-2741a inhibited T cell activation and MCs degranulation, and alleviated house dust miteinduced dermatitis, supporting the therapeutic potential of ORAI1 blockade in allergic diseases (174)

INTRODUCTION Tobacco use remains the leading cause of preventable death and disease in the United States (US) despite the significant decline in commercial use over the past five decades 1