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Some were so ill they needed treatment in intensive care, or were hooked up to ventilators to help them breathe

A Golden Weed: Tobacco and Environment in the Piedmont South (Yale University Press, 2014) 360pp Tilley, Nannie May The Bright Tobacco Industry 18601929 (1948) Tilley, Nannie M

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This is because your body has become dependent on nicotine, the highly addictive substance found in many tobacco and smoking products

Given the possibility that some antidepressants are metabolized by CYP induced or inhibited by substances in tobacco, their identification can be a guide for drug initial choice in smoking patients, allowing a more accurate antidepressant selection and consequently improving the pharmacologic treatment of depression in smokers