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Some higher-dose trials reported weight loss averages up to 20%

Exercise could also regulate intestinal microbiota and induce metabolic improvements by modifying circulating BAs (Aoi et al., 2023)

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Oxidative gene reprogramming ERRs activate hundreds of target genes: mitochondrial biogenesis (NRF1, TFAM), oxidative phosphorylation (complex I, II, III, IV, V subunits), fatty acid beta-oxidation (CPT1B, MCAD, LCAD), Krebs cycle (IDH3, SDHA), type I fiber specification (myoglobin, Myh7, slow troponins), angiogenesis (VEGF-A)