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During curing, several key changes occur: a loss of moisture content of approximately 80% (essential for making the leaves lighter and ready for fermentation), breakdown of sugars and nicotine, oxidation, and a change in color from green to brown [1]

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Emphysema as a Disease of Deficient Tissue Repair/Maintenance Cigarette smoke exposure causes stress responses within the lung, which can initiate processes critical to COPD development

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