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Smoking and Throat Pain From Acid Reflux Smoking has been associated with an increased risk of acid reflux, which can contribute to throat pain and irritation

Misra M, Leverette RD, Cooper BT, Bennett MB, Brown SE

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In the second stage, we regress the outcome variable (the cigarette smoking in this study) on the control variable and the predicted values of the endogenous variable from the first stage (see [25] for more detailed discussion)