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The duration of time that it remains in the body depends on the amount consumed and nicotine half-life

Adults with mental illnesses manifesting within the past month were the most likely to smoke and the least likely to quit

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The two studies that evaluated the effect of smoking on mirtazapines pharmacokinetics show significantly lower mirtazapine and their main active metabolites (S-mirtazapine and R-N-desmethylmirtazapine) serum levels in smokers than in nonsmokers