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The length of time it takes for nicotine to get flushed from your system varies depending on your: Smoking frequency Genetic makeup Age Hormones Liver function Lifestyle Use of certain medications: Antifungals (such as ketoconazole) Medication for high blood pressure (such as amlodipine) Antibiotics (such as rifampin) Phenobarbital Can at-home tests detect the amount of nicotine in your system

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