what is the addictive substance in tobacco smoke Most products, including e-cigarettes, contain nicotine, a chemical that can harm heart, brain and whole body. As with other products, using a nicotine product builds tolerance, leading to more The 10 Most Addictive Substances

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However, according to a new study presented at the American Society of Cell Biology annual meeting in New Orleans, a prolonged exposure to nicotine, either from a real cigarette or the battery operated device can damage the heart, CNN reported