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Sleep is extremely important, especially for mitochondrial health as well

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[Wadden STEP 3, JAMA 2021] STEP 5 Trial (Nature Medicine 2022) Long-term data: patients maintained an average 15.2% weight loss over 2 years of continuous semaglutide use, with sustained metabolic improvements including reduced HbA1c, blood pressure, and waist circumference

This refined understanding of DR as an immunoinflammatory disease provides a strong rationale for exploring immunomodulatory agents like GLP-1RAs