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Patients were stratified into two key subgroups based on antibiotic exposure: ATB 3-3 : Received antibiotics within 3 months before or after ICI start (45% of patients) ATB 1-1 : Received antibiotics within 1 month before or after ICI start (20% of patients) Most antibiotics were prescribed for suspected skin infections (60%), and the most common agents were beta-lactams (45%)

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Handling and usage should be approached with caution, especially for non-smokers or former smokers who are avoiding nicotine reintroduction

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