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See all articles Smoking remains a leading cause of premature death worldwide due to the many serious diseases that disproportionately affect smokers, particularly cardiovascular (heart attack, stroke) and pulmonary (lung cancer, chronic obstructive pulmonary disease) diseases (Figure 1)

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Nicotine: 0.7 mg

However, to date, a causal relationship has not been demonstrated between the use of varenicline and these symptoms, particularly because nicotine dependence and withdrawal syndrome are known to be linked to suicidal ideation, negative affectivity, and depressive symptoms (Jimnez-Ruiz, Berlin, & Hering, 2009