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Three studies were judged to present some concerns for risk of bias, primarily related to small sample sizes, incomplete outcome data, or early termination of follow-up ( 3.2 Sensitivity analysis Excluding the study judged to be at high risk of bias ( 4 Discussion This systemic review and meta-analysis compiled the only available studies that directly evaluated the effect of antioxidant interventions on the incidence of AMS under hypobaric hypoxia conditions in human studies

Consequently, this can cause pre-cancerous lesions like actinic keratoses and non-melanoma skin cancers

As documented in the peer-reviewed literature, GSH serves as a cofactor for glutathione peroxidase (GPx) and glutathione S-transferase (GST), and plays a central role in cellular redox homeostasis (ncbi.nlm.nih.gov, pmc.ncbi.nlm.nih.gov)