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Forty-two RCTs that met the PICO-SD criteria were selected from the systematic review.16, 23, 29, 31, 39, 47, 104, 117, 142, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178, 179, 180 The results showed that bupropion significantly increased smoking cessation success rates at six months or longer compared to placebo (RR, 1.57