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Funding The authors declare that no financial support was received for the research and/or publication of this article

The overall redox state of glutathione [GSH/(GSH + 2GSSG)] in leaf extracts is around 0.90.95

However, under oxidative stress, cysteine residues on KEAP1 are modified, altering its conformation and disrupting its association with NRF2 and subsequent NRF2 stabilization (Taguchi and Yamamoto, 2017)

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Studies have shown that hesperidin can increase AMPK phosphorylation by two-fold and improve glucose uptake in skeletal muscle cells