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In addition to metabolites of carbohydrate and lipid metabolism, amino acids (AAs) have emerged as putative biomarkers for the detection of joint diseases [8], and there are OA-related alterations in the profiles and metabolism of, for instance, glutamic acid and arginine family AAs [9]

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$The activity of short-chain fatty acids (butyrate) on colonocytes is considered an environmental inducer-regulator of apoptosis and proliferation (Figure 2) [81]

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[DOI] [PMC free article] [PubMed] [Google Scholar] [69].Wang B, Zhong J, Lin H, et al