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The absence of nicotine to affect the calming effect may result in an elevation of stress hormones such as cortisol that make it difficult to relax and sleep restoratively

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[583] According to Fernando Negro, a former police chief and then-head of Portugals Institute on Drugs and Drug Addiction, There were fears Portugal might become a drug paradise, but that simply didnt happen. [584] In 2014 researchers studied changes in the social cost of drug use in Portugal, which they defined as a sum of public expenditure on drugs, private costs (incurred by individuals who use drugs) and costs incurred by society (indirect costs, such as lost productivity). [585] They found that the per capita social cost of drug use decreased an overall 18 percent since decriminalization