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showed the diversity of bacterial communities in bronchoalveolar lavage fluid (BALF) from healthy smokers was similar to that from healthy never-smokers, and COPD patients, however, further results from obtained lung tissues of COPD patients unraveled the heterogeneity and diversity in the bacterial microbiota across different regions of the abnormal lung [79], suggesting specific changes in lung microbiome resulted from smoking in COPD patients participate in the occurrence of COPD or exacerbation

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Moreover, between October 2003 and October 2004, and October 2004 and October 2005, the average price of a packet of cigarettes has increased by only 0.16, which is the lowest yearly increase in the past two decades