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Leading obesity researchers emphasize that the goal is to use the lowest dose that achieves the patients clinical targets, treating obesity as a chronic disease rather than pursuing maximum weight loss for its own sake

Daily weight fluctuates by two to five pounds due to water, food in the digestive system, and hormonal changes

Patients should follow the prescribed dosage and consult their healthcare provider before making any changes

Start with conservative measures: consistent sun protection, topical retinoids where appropriate, and moisturizing regimens to support skin quality

Compressing this titration, as some protocols outside clinical trial settings have done, significantly increases the risk of intolerable nausea, vomiting, and dehydration