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Description

Is fundamentally time-dependent

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Corroborating this pathogenic axis, recent studies using cortical neurons derived from patient induced pluripotent stem cells (iPSCs) have demonstrated that presenilin-1 mutations (F105C and A246E) induce pronounced mitochondrial defects, which are remarkably rescued by amyloid precursor protein (APP) knockout, identifying APP as a critical bridging mediator of familial AD-associated mitochondrial dysfunction [45]

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