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comparable to the dose of nicotine to which habitual smokers are exposed, that is, approximately 1 mg/kg/body weight) altered histone acetylation in the testes, ovaries, and lung tissues of F1 offspring and resulted in an asthmatic phenotype

The MOE approach was used for risk assessment 18,19

Lyon, France: World Health Organization

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But the Times Mirror study also noted that even small percentages can translate into millions of people.[245] Bezos later acknowledged that he had not anticipated the importance of those online shoppers, the early adopters who typically have a fairly high tolerance for risk and uncertainty.[246] The thing we had overlooked, at that time, was everybody on the Internet, 100 percent of the population, was what demographers called early adopters, Bezos said