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10.1016/j.freeradbiomed.2008.12.018 243

194, 2018, pp

264,265 Both PMOs and PNAs are neutral nucleic acid analogs with weak binding to plasma proteins, allowing them to be easily cleared by the kidneys

Cheng, Q

Also, it is not known if silymarin absorbed in humans is enough to cross the blood-brain barrier and also the dosage required for optimum effect is yet to be arrived at