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Walesky, C

Scheidegger, M

1517 At higher concentration produced by oxidative stress, 4HNE activates stress activated protein kinases (MAPKs, SAPKs), such as Jun-kinase, to trigger oxidative stress defenses through the AP2 (FOS/JUN heterodimer), NRF2, NFkB, and p53

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Differentiating Changes in Glutathione Levels from Cytotoxic Events Using Multiplexed Assays Alisha Truman and Brad Hook Promega Corporation Publication Date: October 2013 Abstract Measuring changes in glutathione levels as a single endpoint may not be sufficiently informative to differentiate a decrease in GSH from a cytotoxic event