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It showed that CYP2B1 is the major contributor to the metabolism of nicotine, but not the biotransformation of NIC by CYP2C2 and 3A2, and the contribution of CYP1A1, 2A1, 2A2, 2C7, 2C12, 2C13, 2EI and 4A1 to nicotine oxidation was not shown 21

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Table 2 describes the analyses we conducted using data from these information systems, our methodology for testing them, and the result of our assessment which is, the data is not sufficiently reliable for our audit purposes