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[121] Age is also a contributing factor: elderly individuals are often achlorhydric due to reduced parietal cell function in the stomach, increasing their risk of vitamin B 12 deficiency

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Avoid taking with dairy or high-protein meals, which may compete for absorption

Notably, reductions in eGFR slope [53] and UACR [54,55] were more pronounced in people with type 2 diabetes mellitus, suggesting additional kidney-protective mechanisms beyond hemodynamic improvements and albuminuria reduction

Retrieved 18 August 2025