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Clinical trials reveal tirzepatides edge in achieving higher weight loss percentages, often exceeding 20% in non-diabetic obesity patients, while mazdutide shows great results, with up to 14% weight reduction in phase II studies

Mounjaro for diabetes follows standard formulary rules and may be covered with prior authorization

The actual differences in change in body weight (mean difference) for the following comparisons are: Tirzepatide 15mg versus semaglutide 2.0 mg = -5.72Kg (i.e., a mean of 5.72Kg more weight lost in those taking tirzepatide 15mg versus those taking semaglutide 2.0mg) Tirzepatide 10mg versus semaglutide 2.0mg = -3.52 Kg Tirzepatide 5mg versus semaglutide 1.0mg = -1.72 Kg "In summary the three tirzepaide doses were more effective than the three respective semaglutide doses, with the difference between the two drugs being larger with the higher doses, the authors noted

It really made a difference, Jessica concluded

However, if fluid intake does not keep pace with increased urinary output, the net effect can be dehydration, the exact opposite of what urinary health requires