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Importantly, some of the assumptions in both of these models, especially assumptions related to the utilization of medications, were based on data from clinical trials and are unlikely to correspond to findings on the effectiveness of medications outside of a clinical trial setting

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Sinha DN, Gupta PC, Kumar A, Bhartiya D, Agarwal N, Sharma S, Singh H, Parascandola M, Mehrotra R (2018a) The poorest of poor suffer the greatest burden from smokeless tobacco use: a study from 140 countries