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197 ), was not effective in the treatment of recent-onset T1DM 198
As illustrated in Figure 2, pooled analyses of cardiovascular outcome trials have demonstrated that GLP-1 RAs reduce major adverse cardiovascular events (MACEs) by 14% (HR = 0.86, 95% CI 0.790.94) in patients with type 2 diabetes, with additional significant benefits including 13% reduction in cardiovascular death, 16% reduction in nonfatal stroke, and 10% reduction in hospitalization for heart failure [85]
The peptides administration has been linked to the release of serotonin in brain regions associated with mood and motor control, suggesting a bidirectional communication pathway between the gut and the brain
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