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Both diazepam and its major active metabolite desmethyldiazepam bind extensively to plasma proteins (95-98%)

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As the youth e-cigarette epidemic grew, Altria, maker of the best-selling cigarette brand Marlboro, announced it had invested a $12.8 billion stake in JUUL Labs, maker of the top-selling e-cigarette and, in September 2019, an Altria executive was announced as JUULs new CEO