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Some Puff ECs contain synthetic coolant concentrations that are 450 times higher than the concentrations in JUUL (45.1 mg/mL in Puff Plus Cool Mint vs 0.1 mg/mL in JUUL Classic Menthol)

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[38] Spencer's son Giuseppe Pedersoli stated that his father "died without pain in presence of his family, and his last word was ' grazie '"

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Consistently, in Gpr15 +/+ mice, prolonged cigarette smoke exposure in the TNBS model led to aggravated colitis, as reflected by greater weight loss, elevated DAI, colon shortening, and worsened histological and endoscopic scores, accompanied by increased Gpr15 expression (Supplementary Fig