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This is a stable cellular line derivative from PLB-985 that lacks the gp91 phox subunit of the NADPH oxidase 2 (Nox2), because the gp91 phox gene was knocked out [22], which present a reduction of 3 times in the intracellular ROS levels [8]

In mice, the ototoxicity could be mitigated or reversed with NAC.[ref] Gastric bleeding: Similar to NSAIDs, acetaminophen can also increase the risk of gastrointestinal bleeding or ulcers

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