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Any reported association is likely indirect, relating to changes in body composition, posture, or activity levels during weight loss rather than a direct effect of semaglutide

doi: 10.1159/000509583 94 ChouchaniETKazakLSpiegelmanBM

The landmark PREDIMED trial -- a randomized controlled trial involving 7,447 participants -- demonstrated that a Mediterranean diet supplemented with EVOO (approximately 50 g/day) did not result in weight gain over nearly five years of follow-up, despite being an unrestricted-calorie, high-fat diet (Estruch et al., 2018)

After two rounds of design, the most promising sequence (ELGILIFLYLFSLILGIIYWKK) was identified, but its efficacy required validation

What are the side effects of GLP-1 agonists