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By weeks eight to ten, he was tolerating short runs without the sharp pain that had defined his plateau

J Clin Invest 2024;134(17) Acknowledgements We are especially grateful to Novo Nordisk for providing data support

The molecule that emerged from this foundational work carried a disabling flaw as a therapeutic scaffold: native GLP-1 is degraded almost immediately by the serine protease dipeptidyl peptidase-4 (DPP-4), which cleaves the peptide between residues 8 and 9 and confers a circulating half-life of under two minutes [4]

10.1104/pp.114.1.177 Plant Physiol

It also reduces DNA fragmentation in sperm, helps prevent apoptosis, and may improve varicocele-related fertility issues