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For instance, the vitamin is required for the enzymatic reaction that synthesizes the neurotransmitter norepinephrine from dopamine

It is regulated by activation of glutamate receptors, including NmethylDaspartate receptor (NMDAr) [124], amino3hydroxy5methyl4isoxazolepropionicacid receptor (AMPAr), and metabotropic glutamate receptor (mGluR) [125]

While you may potentially notice sleep improvement the day of your first dose or the next day, it can take weeks or even months to notice some of the other benefits

AOD 9604 Dosage and Protocol: What the Research Supports The standard research protocol for AOD 9604 is 300 mcg per day, administered via subcutaneous injection

Mol Pharmacol 2008;74:980989