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Mechanisms supporting harmful effects include: autophagy inhibition (32), promotion of mitochondrial dysfunction and oxidative stress, and interference with neurotransmitter synthesis (103)

Peng et al., 2023

References Rumyantsev, P

One hallmark example is capecitabine-induced diarrhea , which results from its conversion to 5-fluorouracil (5-FU) in the gastrointestinal mucosa via thymidine phosphorylasean enzyme that is upregulated in tumor and normal epithelial tissues