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The levels of nicotine dependence were positively associated with greater pain intensity [24, 25]

[7] Smoking age [edit] The smoking age in Japan has been 20 since 1876

Compared to those using tanks (freebase, adjustable settings), participants using disposable devices (salt, no adjustable settings) were less likely to report quitting or reducing smoking as the primary reason (W2: AOR=0.34

Taken together, the direction of these coefficients aligns with the hypothesized chain linking tobacco dependence to chronic disease through reduced physical activity and worse mental health: higher dependence is associated with lower engagement in health-promoting behavior and elevated depressive symptoms, which in turn correspond to greater chronic disease risk (Figure 1)