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Mutations in both HGF and MET genes are also linked to non-syndromic hearing impairment (NSHI), which is a partial or total loss of hearing that is not associated with other signs and symptoms
IFN- locally increases levels of CXCL9 and CXCL10 in the skin and serum of vitiligo patients, which in turn attracts pathogenic T cells expressing the CXCR3A receptor.18 A predominant lymphocytic infiltrate of CD8+ T cells has been observed in perilesional skin, correlating with disease activity.3 In vitiligo patients, CD8+ T lymphocytes recognize specific melanocyte antigens (MelanA, tyrosinase, gp100, tyrosinase-related proteins 1 and 2, Mart-1)
Tchernof, A., & Despres, J
References Frias JP, Davies MJ, Rosenstock J, et al
Increasing glutathione levels could help prevent free radical damage to cells (Exner 2000)
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